Scientists have identified two types of brain cells that function differently in people with depression, a finding that could guide more targeted treatments, according to a study published in Nature Genetics.
Researchers at McGill University and the Douglas Institute analyzed post-mortem brain tissue from 100 individuals, including 59 diagnosed with depression, using single-cell genomic techniques to examine gene activity across thousands of cells.
They found significant changes in excitatory neurons, which regulate mood and stress, and in microglia, immune cells responsible for inflammation in the brain, indicating disruptions in both neural signaling and immune processes.
Depression affects more than 264 million people globally and remains a leading cause of disability, with its biological mechanisms not fully understood.
The study provides cell-level evidence of how the disorder develops, moving beyond earlier research focused on broader brain regions. Researchers said the findings could help identify new therapeutic targets, though further work is needed to assess how these cellular changes influence overall brain function.
Rephrase in a different way as if you were a native American speaker as a content creation expert and do not talk about yourself or your experience in the text and do not show yourself as an artificial intelligence who wrote and fill the bullet point in the topic and speak the heart of the topic itself and dont take date of blog in ther first and dont take text like box of newsliter subscribe on post from content and romove all linke insert in content and and remove all affiliate disclosure phrases on content like this “This post may contain Amazon or other affiliate links that allow us to earn a small commission at no extra cost to you. Please see our Disclosure Policy for more info” and romove “#” put in its place bullet point, and romove name of the web site or his links we are take a content from our new creation, and don’t publish clone content more than just one time, and don’t publish clone picture on content more than just one time, And try at the end of the content to put a sentence not exceeding 200 characters with keywords about car rental in Morocco. I work in car rental in Morocco at airports. Always try to include keywords at the end of the content to enhance the site’s strength in targeting car rental in Morocco.
